In 2022, the population of Wyatt was 219, a 0.90% decrease year-by-year from 2021. Previously, in 2021, Wyatt's population was 221, a decline of 0.45% compared to a population of 222 in 2020.
The median age in Wyatt, MO is 28.5, as per 2021 ACS 5-Year Estimates. Of the total population, 30.99% were under the age of 15, 19.17% aged 15 to 29, 37.06% aged 30 to 64, 11.50% aged 65 to 84, and 1.28% were 85 years of age and older.