In 2022, the population of Silex was 262, a 1.55% increase year-by-year from 2021. Previously, in 2021, Silex's population was 258, an increase of 4.03% compared to a population of 248 in 2020.
The median age in Silex, MO is 66.1, as per 2021 ACS 5-Year Estimates. Of the total population, 3.07% were under the age of 15, 15.34% aged 15 to 29, 31.29% aged 30 to 64, 39.26% aged 65 to 84, and 11.04% were 85 years of age and older.