In 2022, the population of Pope was 263, a 1.13% decrease year-by-year from 2021. Previously, in 2021, Pope's population was 266, a decline of 0.37% compared to a population of 267 in 2020.
The median age in Pope, MS is 32.5, as per 2021 ACS 5-Year Estimates. Of the total population, 26.91% were under the age of 15, 17.77% aged 15 to 29, 37.87% aged 30 to 64, 16.28% aged 65 to 84, and 1.16% were 85 years of age and older.