The total population of Mclain is estimated to be 367 with 112 males (30.52%) and 255 females (69.48%). There are 143 more females than males in Mclain.
In 2022, the population of Mclain was 316, a 0.63% decrease year-by-year from 2021. Previously, in 2021, Mclain's population was 318, an increase of 1.27% compared to a population of 314 in 2020.
The median age in Mclain, MS is 20.9, as per 2021 ACS 5-Year Estimates. Of the total population, 39.42% were under the age of 15, 15.36% aged 15 to 29, 30.43% aged 30 to 64, 14.20% aged 65 to 84, and 0.58% were 85 years of age and older.