In 2022, the population of Mayo was 1,075, a 0.28% increase year-by-year from 2021. Previously, in 2021, Mayo's population was 1,072, an increase of 1.61% compared to a population of 1,055 in 2020.
The median age in Mayo, FL is 32.6, as per 2021 ACS 5-Year Estimates. Of the total population, 19.02% were under the age of 15, 22.83% aged 15 to 29, 46.94% aged 30 to 64, 9.25% aged 65 to 84, and 1.97% were 85 years of age and older.